Human body temperature and new approaches to constructing temperature-sensitive bacterial vaccines
نویسندگان
چکیده
منابع مشابه
Temperature-sensitive mutant vaccines.
Many live virus vaccines derived by empirical routes exhibit temperature-sensitive (ts) phenotypes. The live virus vaccines that have been outstandingly successful in controlling poliomyelitis are the prime example of this phenomenon. The three live attenuated strains developed by Sabin were derived from wild-type isolates by rapid sequential passage at high multiplicity of infection in monkey ...
متن کاملWarm-Sensitive Neurons that Control Body Temperature
Thermoregulation is one of the most vital functions of the brain, but how temperature information is converted into homeostatic responses remains unknown. Here, we use an unbiased approach for activity-dependent RNA sequencing to identify warm-sensitive neurons (WSNs) within the preoptic hypothalamus that orchestrate the homeostatic response to heat. We show that these WSNs are molecularly defi...
متن کاملSuitability of temperature-sensitive transponders to measure body temperature during animal experiments required for regulatory tests.
Body temperature is a clinical parameter in vaccine quality control to detect systemic side-effects or to monitor progression of infectious diseases. Moreover, changes in body temperature are used as clinical parameters to define humane endpoints in animal experiments. However, measuring body temperature via the rectal route can be troublesome and distressing to the animal. Non-invasive measure...
متن کاملAdiposity and human regional body temperature.
BACKGROUND Human obesity is associated with increased heat production; however, subcutaneous adipose tissue provides an insulating layer that impedes heat loss. To maintain normothermia, therefore, obese individuals must increase their heat dissipation. OBJECTIVE The objective was to test the hypothesis that temperature in a heat-dissipating region of the hand is elevated in obese adults. D...
متن کاملBody temperature
Despite smaller physiological variations (circadian changes, ovulatory cycle, exercise, etc.), deep body temperature is relatively stable (depending on species) due to regulatory processes (Fig. 1). Core temperature is one of the components of milieu intérieur, similarly to other components it contributes to the stability of physiological functions. The basic physiological regulation is determi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cellular and Molecular Life Sciences
سال: 2011
ISSN: 1420-682X,1420-9071
DOI: 10.1007/s00018-011-0734-2